Influence of IS256 on Genome Variability and Formation of Small-Colony Variants in Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus has acquired resistance to nearly all antibiotics used in clinical practice. Whereas some resistance mechanisms are conferred by uptake of resistance genes, others evolve by mutation. In this study, IS256 has been shown to play a role, e.g., in S. aureus strains displaying intermediate resistance to vancomycin (VISA). To characterize the IS256 insertion sites in the genomes of two closely related sequence type 247 (ST247) VISA strains, all insertions were mapped in both VISA and a susceptible control strain. The results showed that the three ST247 strains contained the highest number so far of IS256 insertions for all sequenced S. aureus strains. Furthermore, in contrast to the case with the other IS elements in these genomes,

SUBMITTER: Kleinert F 

PROVIDER: S-EPMC5527575 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature