Antimicrobial Resistance Risks of Cholera Prophylaxis for United Nations Peacekeepers.

ABSTRACT: More than 5 years after a United Nations peacekeeping battalion introduced cholera to Haiti, over 150,000 peacekeepers continue to be deployed annually from countries where cholera is endemic. The United Nations has thus far declined to provide antimicrobial chemoprophylaxis to peacekeepers, a policy based largely on concerns that the risks of drug resistance generation and spread would outweigh the potential benefits of preventing future cholera importations. In this study, we sought to better understand the relative benefits and risks of cholera chemoprophylaxis for peacekeepers in terms of antibiotic resistance. Using a stochastic model to quantify the potential impact of chemoprophylaxis on importation and transmission of drug-resistant and drug-sensitive Vibrio cholerae, we fou

SUBMITTER: Kunkel A 

PROVIDER: S-EPMC5527623 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature