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MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment.

ABSTRACT: The spread of mcr-1-encoding plasmids into carbapenem-resistant Enterobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France.

SUBMITTER: Beyrouthy R 

PROVIDER: S-EPMC5527634 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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MCR-1 and OXA-48 <i>In Vivo</i> Acquisition in KPC-Producing Escherichia coli after Colistin Treatment.

Beyrouthy Racha R   Robin Frederic F   Lessene Aude A   Lacombat Igor I   Dortet Laurent L   Naas Thierry T   Ponties Valérie V   Bonnet Richard R  

Antimicrobial agents and chemotherapy 20170725 8

The spread of <i>mcr-1</i>-encoding plasmids into carbapenem-resistant <i>Enterobacteriaceae</i> raises concerns about the emergence of untreatable bacteria. We report the acquisition of <i>mcr-1</i> in a carbapenem-resistant <i>Escherichia coli</i> strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the <i>Klebsiella pneumoniae</i> carbapenemase-producing <i>E. coli</i> strain acquired two plasmids, an IncL OXA-48-enco  ...[more]

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