Selective Killing of Dormant Mycobacterium tuberculosis by Marine Natural Products.

ABSTRACT: The dormant phenotype acquired by Mycobacterium tuberculosis during infection poses a major challenge in disease treatment, since these bacilli show tolerance to front-line drugs. Therefore, it is imperative to find novel compounds that effectively kill dormant bacteria. By screening 4,400 marine natural product samples against dual-fluorescent M. tuberculosis under both replicating and nonreplicating conditions, we have identified compounds that are selectively active against dormant M. tuberculosis This validates our strategy of screening all compounds in both assays as opposed to using the dormancy model as a secondary screen. Bioassay-guided deconvolution enabled the identification of unique pharmacophores active in each screening model. To confirm the activity of

SUBMITTER: Rodrigues Felix C 

PROVIDER: S-EPMC5527660 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature