Geographic-genetic analysis of <i>Plasmodium falciparum</i> parasite populations from surveys of primary school children in Western Kenya.

ABSTRACT: Background. Malaria control, and finally malaria elimination, requires the identification and targeting of residual foci or hotspots of transmission. However, the level of parasite mixing within and between geographical locations is likely to impact the effectiveness and durability of control interventions and thus should be taken into consideration when developing control programs. Methods. In order to determine the geographic-genetic patterns of Plasmodium falciparum parasite populations at a sub-national level in Kenya, we used the Sequenom platform to genotype 111 genome-wide distributed single nucleotide polymorphic (SNP) positions in 2486 isolates collected from children in 95 primary schools in western Kenya. We analysed these parasite genotypes for genetic stru

SUBMITTER: Omedo I 

PROVIDER: S-EPMC5527688 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature