Divergent Requirements for EZH1 in Heart Development Versus Regeneration.

ABSTRACT:

Rationale

Polycomb repressive complex 2 is a major epigenetic repressor that deposits methylation on histone H3 on lysine 27 (H3K27me) and controls differentiation and function of many cells, including cardiac myocytes. EZH1 and EZH2 are 2 alternative catalytic subunits with partial functional redundancy. The relative roles of EZH1 and EZH2 in heart development and regeneration are unknown.

Objective

We compared the roles of EZH1 versus EZH2 in heart development and neonatal heart regeneration.

Methods and results

Heart development was normal in Ezh1^-/- (Ezh1 knockout) and Ezh2^f/f::cTNT^-Cre (Ezh2 knockout) embryos. Ablation of both genes in Ezh1^-/-::Ezh2^f/f::cTNT^-Cre embryos caused lethal

SUBMITTER: Ai S 

PROVIDER: S-EPMC5527745 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature