FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis.

ABSTRACT:

Background

35% of patients with pancreatic cancer have unresectable locally advanced disease at diagnosis. Several studies have examined systemic chemotherapy with FOLFIRINOX (leucovorin and fluorouracil plus irinotecan and oxaliplatin) in patients with locally advanced pancreatic cancer. We aimed to assess the effectiveness of FOLFIRINOX as first-line treatment in this patient population.

Methods

We systematically searched Embase, MEDLINE (OvidSP), Web of Science, Scopus, PubMed Publisher, Cochrane, and Google Scholar from July 1, 1994, to July 2, 2015, for studies of treatment-naive patients of any age who received FOLFIRINOX as first-line treatment of locally advanced pancreatic cancer. Our primary outcome was overall survival. Secondary outcomes were progression-free sur

SUBMITTER: Suker M 

PROVIDER: S-EPMC5527756 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature