Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression.

ABSTRACT: Glycosylation is the stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process have been associated with malignant transformation. Simultaneous analysis of the expression of all glycan-related genes clearly gives the advantage of enabling a comprehensive view of the genetic background of the glycobiological changes in cancer cells. Studies focusing on the expression of the whole glycome have now become possible, which prompted us to review the present knowledge on glycosylation in relation to breast cancer diagnosis and progression, in the light of available expression data from tumors and breast tissue of healthy individuals. We used various data resources to select a set of 419 functionally relevant genes involved in synthe

SUBMITTER: Potapenko IO 

PROVIDER: S-EPMC5527897 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature