β₁-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β₃AR-Dependent Protective Sphingosine-1 Phosphate Signaling.

ABSTRACT:

Background

Although β-blockers increase survival in patients with heart failure (HF), the mechanisms behind this protection are not fully understood, and not all patients with HF respond favorably to them. We recently showed that, in cardiomyocytes, a reciprocal down-regulation occurs between β₁-adrenergic receptors (ARs) and the cardioprotective sphingosine-1-phosphate (S1P) receptor-₁ (S1PR₁).

Objectives

The authors hypothesized that, in addition to salutary actions due to direct β₁AR-blockade, agents such as metoprolol (Meto) may improve post-myocardial infarction (MI) structural and functional outcomes via restored S1PR₁ signaling, and sought to determine mechanisms accounting for this effect.

Methods

We teste

SUBMITTER: Cannavo A 

PROVIDER: S-EPMC5527977 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature