Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials.

ABSTRACT:

Objective

To determine the efficacy and tolerability of topical pimecrolimus and tacrolimus compared with other treatments for atopic dermatitis.

Design

Systematic review and meta-analysis.

Data sources

Electronic searches of the Cochrane Library, Medline, and Embase.

Study selection

Randomised controlled trials of topical pimecrolimus or tacrolimus reporting efficacy outcomes or tolerability.

Data extraction

Efficacy

investigators' global assessment of response; patients' global assessment of response; proportions of patients with flares of atopic dermatitis; and improvements in quality of life. Tolerability: overall rates of withdrawal; withdrawal due to adverse events; and proportions of patients with burning of the skin and skin infections.

SUBMITTER: Ashcroft DM 

PROVIDER: S-EPMC552812 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature