Prostate-specific membrane antigen targeted protein contrast agents for molecular imaging of prostate cancer by MRI.

ABSTRACT: Prostate-specific membrane antigen (PSMA) is one of the most specific cell surface markers for prostate cancer diagnosis and targeted treatment. However, achieving molecular imaging using non-invasive MRI with high resolution has yet to be achieved due to the lack of contrast agents with significantly improved relaxivity for sensitivity, targeting capabilities and metal selectivity. We have previously reported our creation of a novel class of protein Gd(3+) contrast agents, ProCA32, which displayed significantly improved relaxivity while exhibiting strong Gd(3+) binding selectivity over physiological metal ions. In this study, we report our effort in further developing biomarker-targeted protein MRI contrast agents for molecular imaging of PSMA. Among three PSMA targeted contrast agents en

SUBMITTER: Pu F 

PROVIDER: S-EPMC5528195 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature