Transcriptional modulation induced by ionizing radiation: p53 remains a central player.

ABSTRACT: The cellular response to DNA damage is vital for maintaining genomic stability and preventing undue cell death or cancer formation. The DNA damage response (DDR), most robustly mobilized by double-strand breaks (DSBs), rapidly activates an extensive signaling network that affects numerous cellular systems, leading to cell survival or programmed cell death. A major component of the DDR is the widespread modulation of gene expression. We analyzed together six datasets that probed transcriptional responses to ionizing radiation (IR) - our novel experimental data and 5 published datasets - to elucidate the scope of this response and identify its gene targets. According to the mRNA expression profiles we recorded from 5 cancerous and non-cancerous human cell lines after exposure to 5 Gy of IR,

SUBMITTER: Rashi-Elkeles S 

PROVIDER: S-EPMC5528315 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature