Claudin-2 is an independent negative prognostic factor in breast cancer and specifically predicts early liver recurrences.

ABSTRACT:

Background

Predicting any future metastatic site of early-stage breast cancer is important as it significantly influences the prognosis of advanced disease. This study aimed at investigating the potential of claudin-2, over-expressed in breast cancer liver metastases, as a biomarker for predicting liver metastatic propensity in primary breast cancer.

Methods

Claudin-2 expression was analyzed in two independent cohorts. Cohort 1 included 304 women with metastatic breast cancer diagnosed between 2002 and 2007, while cohort 2 included 237 premenopausal women with early-stage node-negative breast cancer diagnosed between 1991 and 1994. Global transcriptional profiling of fine-needle aspirates from metastases was performed, followed by immunohistochemical analyses in archival pri

SUBMITTER: Kimbung S 

PROVIDER: S-EPMC5528500 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature