Breast cancer prognosis predicted by nuclear receptor-coregulator networks.

ABSTRACT: Although molecular signatures based on transcript expression in breast cancer samples have provided new insights into breast cancer classification and prognosis, there are acknowledged limitations in current signatures. To provide rational, pathway-based signatures of disrupted physiology in cancer tissues that may be relevant to prognosis, this study has directly quantitated changed gene expression, between normal breast and cancer tissue, as a basis for signature development. The nuclear receptor (NR) family of transcription factors, and their coregulators, are fundamental regulators of every aspect of metazoan life, and were rigorously quantified in normal breast tissues and ERα positive and ERα negative breast cancers. Coregulator expression was highly correlated with that of selected

SUBMITTER: Doan TB 

PROVIDER: S-EPMC5528526 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature