Breast tumor PDXs are genetically plastic and correspond to a subset of aggressive cancers prone to relapse.

ABSTRACT: Patient derived xenografts (PDXs) are increasingly appreciated models in cancer research, particularly for preclinical testing, as they reflect the patient's tumor biology more accurately than cancer cell lines. We have established a collection of 20 breast PDXs and characterized their biological and clinical features, as well as their genetic stability. While most PDXs originated from triple negative breast cancers (70%), our collection comprised five ER + cases (25%). Remarkably, the tumors that produced PDXs derived from a subset of aggressive breast cancers with a high proportion of grade 3 tumors and reduced recurrence-free survival. Consistent with this, we found significant differences between the transcriptomic signatures of tumors that produced a PDX (Take) and those that did not

SUBMITTER: du Manoir S 

PROVIDER: S-EPMC5528550 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature