Subtype-dependent prognostic relevance of an interferon-induced pathway metagene in node-negative breast cancer.

ABSTRACT: The majority of gene expression signatures developed to predict the likelihood to relapse in breast cancer (BC) patients assigns a high risk score to patients with Estrogen Receptor (ER) negative or highly proliferating tumors. We aimed to identify a signature of differentially expressed (DE) metagenes, rather than single DE genes, associated with distant metastases beyond classical risk factors. We used 105 gene expression profiles from consecutive BCs to identify metagenes whose prognostic role was defined on an independent series of 92 ESR1+/ERBB2- node-negative BCs (42 cases developing metastases within 5 years from diagnosis and 50 cases metastasis-free for more than 5 years, comparable for age, tumor size, ER status and surgery). Findings were validated on publicly available datasets

SUBMITTER: Callari M 

PROVIDER: S-EPMC5528564 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature