Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells.

ABSTRACT: Glioblastoma is deemed the most malignant form of brain tumour, particularly due to its resistance to conventional treatments. A small surviving group of aberrant stem cells termed glioma initiation cells (GICs) that escape surgical debulking are suggested to be the cause of this resistance. Relatively quiescent in nature, GICs are capable of driving tumour recurrence and undergo lineage differentiation. Most importantly, these GICs are resistant to radiotherapy, suggesting that radioresistance contribute to their survival. In a previous study, we demonstrated that GICs had a restricted double strand break (DSB) repair pathway involving predominantly homologous recombination (HR) associated with a lack of functional G1/S checkpoint arrest. This unusual behaviour led to less efficient non-h

SUBMITTER: Lim YC 

PROVIDER: S-EPMC5528585 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature