Multi-level gene expression signatures, but not binary, outperform Ki67 for the long term prognostication of breast cancer patients.

ABSTRACT: Proliferation-related gene signatures have been proposed to aid breast cancer management by providing reproducible prognostic and predictive information on a patient-by-patient basis. It is unclear however, whether a less demanding assessment of cell division rate (as determined in clinical setting by expression of Ki67) can function in place of gene profiling. We investigated agreement between literature-, distribution-based, as well as signature-derived values for Ki67, relative to the genomic grade index (GGI), 70-gene signature, p53 signature, recurrence score (RS), and the molecular subtype models of Sorlie, Hu, and Parker in representative sets of 253 and 159 breast cancers with a median follow-up of 13 and 14.5 years, respectively. The relevance for breast cancer specific survival w

SUBMITTER: Tobin NP 

PROVIDER: S-EPMC5528643 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature