The histone chaperone HJURP is a new independent prognostic marker for luminal A breast carcinoma.

ABSTRACT:

Background

Breast cancer is a heterogeneous disease with different molecular subtypes that have varying responses to therapy. An ongoing challenge in breast cancer research is to distinguish high-risk patients from good prognosis patients. This is particularly difficult in the low-grade, ER-positive luminal A tumors, where robust diagnostic tools to aid clinical treatment decisions are lacking. Recent data implicating chromatin regulators in cancer initiation and progression offers a promising avenue to develop new tools to help guide clinical decisions.

Methods

Here we exploit a published transcriptome dataset and an independent validation cohort to correlate the mRNA expression of selected chromatin regulators with respect to the four intrinsic breast cancer molecular subt

SUBMITTER: Montes de Oca R 

PROVIDER: S-EPMC5528705 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature