Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment.

ABSTRACT:

Objective

HIV-infected monocytes can infiltrate the blood brain barrier as differentiated macrophages to the central nervous system, becoming the primary source of viral and cellular neurotoxins. The final outcome is HIV-associated cognitive impairment (HACI), which remain prevalent today, possibly due to the longer life-span of the patients treated with combined anti-retroviral therapy. Our main goal was to characterize the proteome of monocyte-derived macrophages (MDM) from HACI patients, and its association with their cognitive status, to find novel targets for therapy.

Methods

MDM were isolated from the peripheral blood of 14 HIV-seropositive women characterized for neurocognitive function, including: four normal cognition (NC), five asymptomatic (A), and five with cogni

SUBMITTER: Cantres-Rosario YM 

PROVIDER: S-EPMC5528838 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature