Immunological and inflammatory mapping of vascularized composite allograft rejection processes in a rat model.

ABSTRACT:

Background

Hand and face vascularized composite allotransplantation (VCA) is an evolving and challenging field with great opportunities. During VCA, massive surgical damage is inflicted on both donor and recipient tissues, which may contribute to the high VCA rejection rates. To segregate between the damage-induced and rejection phase of post-VCA responses, we compared responses occurring up to 5 days following syngeneic versus allogeneic vascularized groin flap transplantations, culminating in transplant acceptance or rejection, respectively.

Methods

The immune response elicited upon transplantation of a syngeneic versus allogeneic vascularized groin flap was compared at Post-operative days 2 or 5 by histology, immunohistochemistry and by broad-scope gene and protein analys

SUBMITTER: Friedman O 

PROVIDER: S-EPMC5528841 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature