Serum N-glycan analysis in breast cancer patients--Relation to tumour biology and clinical outcome.

ABSTRACT: Glycosylation and related processes play important roles in cancer development and progression, including metastasis. Several studies have shown that N-glycans have potential diagnostic value as cancer serum biomarkers. We have explored the significance of the abundance of particular serum N-glycan structures as important features of breast tumour biology by studying the serum glycome and tumour transcriptome (mRNA and miRNA) of 104 breast cancer patients. Integration of these types of molecular data allows us to study the relationship between serum glycans and transcripts representing functional pathways, such as metabolic pathways or DNA damage response. We identified tri antennary trigalactosylated trisialylated glycans in serum as being associated with lower levels of tumour transcript

SUBMITTER: Haakensen VD 

PROVIDER: S-EPMC5528923 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature