CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway.

ABSTRACT: CBP (CREB-binding protein) is a transcriptional co-activator which possesses HAT (histone acetyltransferases) activity and participates in many biological processes, including embryonic development, growth control and homeostasis. However, its roles and the underlying mechanisms in the regulation of carcinogenesis and tumor development remain largely unknown. Here we investigated the molecular mechanisms and potential targets of CBP involved in tumor growth and survival in lung cancer cells. Elevated expression of CBP was detected in lung cancer cells and tumor tissues compared to the normal lung cells and tissues. Knockdown of CBP by siRNA or inhibition of its HAT activity using specific chemical inhibitor effectively suppressed cell proliferation, migration and colony formation and induc

SUBMITTER: Tang Z 

PROVIDER: S-EPMC5528962 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature