Proteome analysis of sheep B lymphocytes in the course of bovine leukemia virus-induced leukemia.

ABSTRACT: Presented are the results of a study of the expression pattern of different proteins in the course of bovine leukemia virus-induced leukemia in experimental sheep and I discuss how the obtained data may be useful in gaining a better understanding of the pathogenesis of the disease, diagnosis, and for the selection of possible therapeutic targets. In cattle, the disease is characterized by life-long persistent lymphocytosis leading to leukemia/lymphoma in about 5% of infected animals. In sheep, as opposed to cattle, the course of the disease is always fatal and clinical symptoms usually occur within a three-year period after infection. For this reason, sheep are an excellent experimental model of retrovirus-induced leukemia. This model can be useful for human pathology, as bovine leukemia v

SUBMITTER: Reichert M 

PROVIDER: S-EPMC5529001 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature