Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography.

ABSTRACT: Purpose To investigate the utility of magnetic resonance (MR) elastography-derived mechanical properties in the discrimination of hepatic inflammation and fibrosis in the early stages of chronic liver diseases. Materials and Methods All studies were approved by the institutional animal care and use committee. A total of 187 animals were studied, including 182 mice and five pigs. These animals represented five different liver diseases with a varying combination and extent of hepatic inflammation, fibrosis, congestion, and portal hypertension. Multifrequency three-dimensional MR elastography was performed, and shear stiffness, storage modulus, shear loss modulus, and damping ratio were calculated for all animals. Necroinflammation, fibrosis, and portal pressure were either histologically sco

SUBMITTER: Yin M 

PROVIDER: S-EPMC5529282 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature