Deciphering mechanisms of acquired T790M mutation after EGFR inhibitors for NSCLC by computational simulations.

ABSTRACT: Metastatic non-small-cell lung cancer (NSCLC) with activating EGFR mutations responds very well to first and second generation tyrosine-kinase inhibitors (TKI) including gefitinib, erlotinib and afatinib. Unfortunately, drug resistance will eventually develop and about half of the cases are secondary to the emergence of acquired T790M somatic mutation. In this work, we prospectively recruited 68 patients with metastatic EGFR-mutated NSCLC who have developed progressive disease after first-line TKI with or without subsequent TKI and/or other systemic therapy. Liquid biopsy after progression to their last line of systemic therapy were taken for detection of acquired T790M mutation. By performing attribute ranking we found that several attributes, including the initial EGFR mutational type, h

SUBMITTER: Zou B 

PROVIDER: S-EPMC5529360 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature