Parallel comparative studies on toxicity of quantum dots synthesized and surface engineered with different methods in vitro and in vivo.

ABSTRACT: Quantum dots (QDs) have been considered to be promising probes for biosensing, bioimaging, and diagnosis. However, their toxicity issues caused by heavy metals in QDs remain to be addressed, in particular for their in vivo biomedical applications. In this study, a parallel comparative investigation in vitro and in vivo is presented to disclose the impact of synthetic methods and their following surface modifications on the toxicity of QDs. Cellular assays after exposure to QDs were conducted including cell viability assessment, DNA breakage study in a single cellular level, intracellular reactive oxygen species (ROS) receptor measurement, and transmission electron microscopy to evaluate their toxicity in vitro. Mice experiments after QD administration, including analysis of hemobiological

SUBMITTER: Liu F 

PROVIDER: S-EPMC5529378 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature