Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study.

ABSTRACT: Bariatric surgery is an effective method to rapidly induce weight loss in severely obese people, however its impact on brain functional connectivity after longer periods of follow-up is yet to be assessed. We investigated changes in connectivity in 16 severely obese women one month before, one month after and one year after Roux-en-Y gastric bypass surgery (RYGB). 12 lean controls were also enrolled. Resting-state fMRI was acquired for all participants following an overnight fast and after a 260 kcal load. Connectivity between regions involved in food-related saliency attribution and reward-driven eating behavior was stronger in presurgery patients compared to controls, but progressively weakened after follow-up. At one year, changes in networks related to cognitive control over eating and

SUBMITTER: Olivo G 

PROVIDER: S-EPMC5529553 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature