DNA methylation signatures of chronic alcohol dependence in purified CD3⁺ T-cells of patients undergoing alcohol treatment.

ABSTRACT: Several studies have shown an association of alcohol dependence with DNA methylation (DNAm), suggesting that environmentally-induced changes on epigenomic variation may play an important role in alcohol dependence. In the present study, we analysed genome-wide DNAm profiles of purified CD3⁺ T-cells from pre- and post-treatment alcohol dependent patients, as well as closely matched healthy controls. We identified 59 differentially methylated CpG sites comparing patients prior to treatment with healthy controls and were able to confirm 8 of those sites in additional analyses for differentially methylated regions. Comparing patients before and after a 3-week alcohol treatment program we revealed another unique set of 48 differentially methylated CpG sites. Additionally, we found th

SUBMITTER: Bruckmann C 

PROVIDER: S-EPMC5529570 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature