Early functional network alterations in asymptomatic elders at risk for Alzheimer's disease.

ABSTRACT: Amyloid-β (Aβ) deposition is known to starts decades before the onset of clinical symptoms of Alzheimer's disease (AD), however, the detailed pathophysiological processes underlying this preclinical period are not well understood. This study aimed to investigate functional network alterations in cognitively intact elderly individuals at risk for AD, and assessed the association between these network alterations and changes in Aβ deposition, glucose metabolism, and brain structure. Forty-five cognitively normal elderly subjects, who were classified into Aβ-positive (CN+) and Aβ-negative (CN-) groups using ¹¹C-Pittsburgh compound B PET, underwent resting state magnetoencephalography measurements, ¹⁸F-fluorodeoxyglucose PET (FDG-PET) and structural MRI. Results demonstra

SUBMITTER: Nakamura A 

PROVIDER: S-EPMC5529571 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature