Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis.

ABSTRACT: Monocytes/macrophages are critical in systemic and local inflammation in giant cell arteritis (GCA) and possibly in clinically overlapping polymyalgia rheumatica (PMR). Therefore, we aimed to understand the contribution of monocyte subsets and the CX3CR1-CX3CL1 and CCR2-CCL2 migratory pathways, to the pathology of GCA. Peripheral blood monocytes were enumerated in samples from newly-diagnosed, untreated GCA and PMR patients and after prednisone-induced remission. The distribution of classical (CD14^brightCD16^neg) and the more pro-inflammatory, intermediate (CD14^brightCD16+) and non-classical (CD14^dimCD16+) monocyte subsets was analysed by flow cytometry. The phenotype of macrophages in temporal artery biopsies (TABs) from GCA patients was studied

SUBMITTER: van Sleen Y 

PROVIDER: S-EPMC5529580 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature