A cooperative polymeric platform for tumor-targeted drug delivery.

ABSTRACT: In the pursuit of effective treatments for cancer, an emerging strategy is "active targeting", where nanoparticles are decorated with targeting ligands able to recognize and bind specific receptors overexpressed by tumor cells or tumor vasculature so that a greater fraction of the administered drugs are selectively trafficked to tumor sites. However, the implementation of this strategy has faced a major obstacle. The interpatient, inter- and intra-tumoral heterogeneity in receptor expression can pose challenges for the design of clinical trials and result in the paucity of targetable receptors within a tumor, which limits the effectiveness of "active targeting" strategy in cancer treatment. Here we report a cooperative drug delivery platform that overcomes the heterogeneity barrier unique

SUBMITTER: Song W 

PROVIDER: S-EPMC5530016 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature