Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action.

ABSTRACT:

Objective

Many types of treatment are available for patients with rheumatoid arthritis (RA), however, some patients fail to achieve remission. This report aims to determine the safety and efficacy of using repository corticotropin injection (RCI) as an adjunctive therapy in patients with RA refractory to at least three therapeutics with different mechanisms of action.

Method

In this open-label, interventional, single-group study, patients received 80 U RCI twice weekly via subcutaneous injection over 12 weeks. Changes in the Ritchie-Camp Articular Index and health assessment questionnaire scores were monitored for changes from baseline measures.

Results

Eight patients were enrolled and consisted of seven females and one male with an average age of 64.6 years and disea

SUBMITTER: Gillis T 

PROVIDER: S-EPMC5530054 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature