Lack of change in glucose metabolism in eszopiclone-treated primary insomnia patients.

ABSTRACT:

Study objectives

Primary insomnia (PI) may increase diabetes risk. We tested the hypothesis that the effects of PI on glucose metabolism could be improved by 2 months of pharmacological treatment.

Methods

Adult men and women meeting clinical criteria for PI were studied (n=20, body mass index 25.1±2.7 kg/m², age 39.7±7.9) in a randomized, double-blind, placebo-controlled clinical trial. The study consisted of two 1-day inpatient admissions to a General Clinical Research Center separated by 2 months of at-home treatment with 3 mg eszopiclone or placebo. During inpatient admissions, each subject underwent two intravenous glucose tolerance tests (IVGTTs) pre- and post-treatment. Diet was controlled for micro- and macro-nutrient content and calories on the day prior t

SUBMITTER: Buxton OM 

PROVIDER: S-EPMC5530064 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature