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Understanding CARD Tricks in Apoptosomes.

ABSTRACT: While earlier studies of Apaf-1 holo-apoptosome architecture revealed the spectacular heptameric wheel-like structure formed by Apaf-1, the central CARD disk responsible for caspase-9 recruitment remained incompletely resolved. In a recent issue of Structure, Su et al. (2017) describe a crystal structure of the complex between Apaf-1 CARD and caspase-9 CARD. Together with two recent cryo-EM structures, this work brings us closer to a full view of the holo-apoptosome.

SUBMITTER: Wang L 

PROVIDER: S-EPMC5530255 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Understanding CARD Tricks in Apoptosomes.

Wang Li L   Qiao Qi Q   Wu Hao H  

Structure (London, England : 1993) 20170401 4

While earlier studies of Apaf-1 holo-apoptosome architecture revealed the spectacular heptameric wheel-like structure formed by Apaf-1, the central CARD disk responsible for caspase-9 recruitment remained incompletely resolved. In a recent issue of Structure, Su et al. (2017) describe a crystal structure of the complex between Apaf-1 CARD and caspase-9 CARD. Together with two recent cryo-EM structures, this work brings us closer to a full view of the holo-apoptosome. ...[more]

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