A novel protein expression signature differentiates benign lipomas from well-differentiated liposarcomas.

ABSTRACT: Benign lipomas and well-differentiated liposarcomas share many histological and molecular features. Due to their similarities, patients with these lipomatous tumors are misdiagnosed up to 40% of the time following radiological detection, up to 17% of the time following histological examination, and in as many as 15% of cases following fluorescent in situ hybridization for chromosomal anomalies. Incorrect classification of these two tumor types leads to increased costs to the patient and delayed accurate diagnoses. In this study, we used genomics analysis to identify several genes whose mRNA expression patterns were significantly altered between lipomas and well-differentiated liposarcomas. We confirmed our findings at the protein level using a panel of 30 human lipomatous tumors, re

SUBMITTER: Mather Q 

PROVIDER: S-EPMC5530308 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature