A rare coding allele in IFIH1 is protective for psoriatic arthritis.

ABSTRACT:

Objectives

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. While many common risk alleles have been reported for association with PsA as well as psoriasis, few rare coding alleles have yet been identified.

Methods

To identify rare coding variation associated with PsA risk or protection, we genotyped 41 267 variants with the exome chip and investigated association within an initial cohort of 1980 PsA cases and 5913 controls. Genotype data for an independent cohort of 2234 PsA cases and 5708 controls was also made available, allowing for a meta-analysis to be performed with the discovery dataset.

Results

We identified an association with the rare variant rs35667974 (p=2.39x10^-6, OR=0.47), encoding an Ile923Val amino acid chan

SUBMITTER: Budu-Aggrey A 

PROVIDER: S-EPMC5530346 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature