Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital.

ABSTRACT: The carcinogenic potential of phenobarbital (PB) was assessed in a mouse line carrying a mutant Mmh allele of the Mmh/Ogg1 gene encoding the enzyme oxoguanine DNA glycosylase (Ogg1) responsible for the repair of 8-hydroxy-2'-deoxyguanosine (8-OHdG). Mmh homozygous mutant (Ogg1^-/-) and wild-type (Ogg1^+/+) male and female, 10-week-old, mice were treated with 500 ppm PB in diet for 78 weeks. Hepatocellular carcinomas (HCCs) were found in PB-treated Ogg1^-/- mice, while Ogg1^+/+ animals developed only hepatocellular adenomas (HCAs) at the same rate. This was coordinated with PB-induced significant elevation of 8-OHdG formation in DNA and cell proliferation in adjacent liver of Ogg1^-/- m

SUBMITTER: Kakehashi A 

PROVIDER: S-EPMC5530452 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature