Globally weaker and topologically different: resting-state connectivity in youth with autism.

ABSTRACT:

Background

There is a lack of agreement about functional connectivity differences in individuals with autism spectrum disorder (ASD). Studies using absolute strength have found reduced connectivity, while those using relative strength--a measure of system topology--reveal mostly enhanced connectivity. We hypothesized that mixed findings may be driven by the metric of functional connectivity.

Methods

Resting-state echo planar 3 T functional magnetic resonance imaging scans were acquired on a Siemens Verio Scanner from 6 to 17-year-old youth with ASD (n = 81) and a matched typically developing control group (n = 82). All functional time series data were preprocessed using a confound regression procedure that has been previously validated in large-scale developmen

SUBMITTER: Yerys BE 

PROVIDER: S-EPMC5530457 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature