Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function.

ABSTRACT:

Background

There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail. For identifying regions of common methylation differences, we used whole genome bisulfite sequencing data of monocytes from five donors and a novel bioinformatic strategy.

Results

We identified 157 differentially methylated regions (DMRs) with four or more CpGs, almost none of which has been described before. The DMRs fall into different chromatin states, where methylation is inversely correlated with active, but not repressive histone marks. However, methylation is not correlated with the expression of associated genes. High-resolution single nucleotide po

SUBMITTER: Schroder C 

PROVIDER: S-EPMC5530492 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature