Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis.

ABSTRACT:

Background

The assessment and characterization of the gut microbiome has become a focus of research in the area of human autoimmune diseases. Ankylosing spondylitis is an inflammatory autoimmune disease and evidence showed that ankylosing spondylitis may be a microbiome-driven disease.

Results

To investigate the relationship between the gut microbiome and ankylosing spondylitis, a quantitative metagenomics study based on deep shotgun sequencing was performed, using gut microbial DNA from 211 Chinese individuals. A total of 23,709 genes and 12 metagenomic species were shown to be differentially abundant between ankylosing spondylitis patients and healthy controls. Patients were characterized by a form of gut microbial dysbiosis that is more prominent than previously reported

SUBMITTER: Wen C 

PROVIDER: S-EPMC5530561 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature