Ontology highlight
ABSTRACT:
SUBMITTER: da Silva-Coelho P
PROVIDER: S-EPMC5530598 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Nature communications 20170421
Cancer development is a dynamic process during which the successive accumulation of mutations results in cells with increasingly malignant characteristics. Here, we show the clonal evolution pattern in myelodysplastic syndrome (MDS) patients receiving supportive care, with or without lenalidomide (follow-up 2.5-11 years). Whole-exome and targeted deep sequencing at multiple time points during the disease course reveals that both linear and branched evolutionary patterns occur with and without di ...[more]