A new member of the fusaricidin family - structure elucidation and synthesis of fusaricidin E.

ABSTRACT: Two hitherto unknown fusaricidins were obtained from fermentation broths of three Paenibacillus strains. After structure elucidation based on tandem mass spectrometry and NMR spectroscopy, fusaricidin E was synthesized to confirm the structure and the suggested stereochemistry. The synthesis was based on a new strategy which includes an efficient access to the 15-guanidino-3-hydroxypentadecanoyl (GHPD) side chain from erucamide.

SUBMITTER: Reimann M 

PROVIDER: S-EPMC5530608 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature