Calcium fluoride based multifunctional nanoparticles for multimodal imaging.

ABSTRACT: New multifunctional nanoparticles (NPs) that can be used as contrast agents (CA) in different imaging techniques, such as photoluminescence (PL) microscopy and magnetic resonance imaging (MRI), open new possibilities for medical imaging, e.g., in the fields of diagnostics or tissue characterization in regenerative medicine. The focus of this study is on the synthesis and characterization of CaF₂:(Tb³⁺,Gd³⁺) NPs. Fabricated in a wet-chemical procedure, the spherical NPs with a diameter of 5-10 nm show a crystalline structure. Simultaneous doping of the NPs with different lanthanide ions, leading to paramagnetism and fluorescence, makes them suitable for MR and PL imaging. Owing to the Gd³⁺ ions on the surface, the NPs reduce the MR T_1<

SUBMITTER: Straßer M 

PROVIDER: S-EPMC5530611 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature