Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment.

ABSTRACT:

Background

We previously found that subjects with amnestic mild cognitive impairment exhibit a pro-inflammatory immune profile in the cerebrospinal fluid similar to multiple sclerosis, a central nervous system autoimmune disease. We therefore hypothesized that early neuroinflammation would reflect increases in brain amyloid burden during amnestic mild cognitive impairment.

Methods

Cerebrospinal fluid and blood samples were collected from 24 participants with amnestic mild cognitive impairment (12 men, 12 women; 66 ± 6 years; 0.5 Clinical Dementia Rating) enrolled in the AETMCI study. Analyses of cerebrospinal fluid and blood included immune profiling by multi-parameter flow cytometry, genotyping for apolipoprotein (APO)ε, and quantification of cytokine and immunoglobin level

SUBMITTER: Stowe AM 

PROVIDER: S-EPMC5530920 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature