Behavioural and neuroanatomical correlates of auditory speech analysis in primary progressive aphasias.

ABSTRACT:

Background

Non-verbal auditory impairment is increasingly recognised in the primary progressive aphasias (PPAs) but its relationship to speech processing and brain substrates has not been defined. Here we addressed these issues in patients representing the non-fluent variant (nfvPPA) and semantic variant (svPPA) syndromes of PPA.

Methods

We studied 19 patients with PPA in relation to 19 healthy older individuals. We manipulated three key auditory parameters-temporal regularity, phonemic spectral structure and prosodic predictability (an index of fundamental information content, or entropy)-in sequences of spoken syllables. The ability of participants to process these parameters was assessed using two-alternative, forced-choice tasks and neuroanatomical associations of task p

SUBMITTER: Hardy CJD 

PROVIDER: S-EPMC5531024 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature