A highly selective near-infrared fluorescent probe for imaging H₂Se in living cells and in vivo.

ABSTRACT: Hydrogen selenide (H₂Se), a highly reactive Se species, is an important selenium metabolism intermediate involved in many physiological and pathological processes. This compound is of scientific interest with regard to the real-time monitoring of H₂Se in living cells and in vivo to understand the anti-cancer mechanism of selenium. However, monitoring H₂Se in living cells is still challenging due to the lack of straight forward, highly selective and rapid methods. Here, we developed a novel small-molecule fluorescent probe, NIR-H₂Se, for imaging endogenous H₂Se. NIR-H₂Se exhibited high selectivity toward H₂Se over selenocysteine (Sec), H₂S and small molecule thiols and was successful

SUBMITTER: Kong F 

PROVIDER: S-EPMC5531029 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature