Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles.

ABSTRACT: The rise of hospital-acquired infections, also known as nosocomial infections, is a growing concern in intensive healthcare, causing the death of hundreds of thousands of patients and costing billions of dollars worldwide every year. In addition, a decrease in the effectiveness of antibiotics caused by the emergence of drug resistance in pathogens living in biofilm communities poses a significant threat to our health system. The development of new therapeutic agents is urgently needed to overcome this challenge. We have developed new dual action polymeric nanoparticles capable of storing nitric oxide, which can provoke dispersal of biofilms into an antibiotic susceptible planktonic form, together with the aminoglycoside gentamicin, capable of killing the bacteria. The novelty of this work

SUBMITTER: Nguyen TK 

PROVIDER: S-EPMC5531038 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature