Increased Extra-axial Cerebrospinal Fluid in High-Risk Infants Who Later Develop Autism.

ABSTRACT:

Background

We previously reported that infants who developed autism spectrum disorder (ASD) had increased cerebrospinal fluid (CSF) in the subarachnoid space (i.e., extra-axial CSF) from 6 to 24 months of age. We attempted to confirm and extend this finding in a larger independent sample.

Methods

A longitudinal magnetic resonance imaging study of infants at risk for ASD was carried out on 343 infants, who underwent neuroimaging at 6, 12, and 24 months. Of these infants, 221 were at high risk for ASD because of an older sibling with ASD, and 122 were at low risk with no family history of ASD. A total of 47 infants were diagnosed with ASD at 24 months and were compared with 174 high-risk and 122 low-risk infants without ASD.

Results

Infants who developed ASD had signifi

SUBMITTER: Shen MD 

PROVIDER: S-EPMC5531051 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature