Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.

ABSTRACT:

Background

The infection of a participant with norovirus during the adaptive study of interleukin-2 dose on regulatory T cells in type 1 diabetes (DILT1D) allowed a detailed insight into the cellular and cytokine immune responses to this prevalent gastrointestinal pathogen.

Methods

Serial blood, serum and peripheral blood mononuclear cell (PBMC) samples were collected pre-, and post-development of the infection. To differentiate between the immune response to norovirus and to control for the administration of a single dose of aldesleukin (recombinant interleukin-2, rIL-2) alone, samples from five non-infected participants administered similar doses were analysed in parallel.

Results

Norovirus infection was self-limited and resolved within 24 hours, with the subsequent

SUBMITTER: Cutler AJ 

PROVIDER: S-EPMC5531165 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature